Lion's Mane mushroom is a unique and powerful nootropic that has recently gained popularity due to its potential health benefits. It is a type of mushroom that has been used in traditional Chinese and Japanese medicine for centuries. It has been used to treat various ailments, including digestive issues, fatigue, and even cancer. 

Recent research has also suggested that Lion's Mane can be used to improve cognitive function and focus, making it a potential natural treatment for Attention Deficit Hyperactivity Disorder (ADHD). This article will discuss what Lion's Mane is, how it works, and its potential benefits for ADHD. We'll also look at the potential side effects and how to take it safely and answer some frequently asked questions.

What Are Lion's Mane Mushrooms?

Lion's Mane mushrooms are a type of edible mushroom that has been used for centuries in traditional Chinese as a tonic medicine. 

The mushroom is native to North America, Europe, and Asia and is known for its unique appearance - it looks like a white, shaggy mane. Studies have found that Lion's Mane mushrooms contain compounds that can help protect the brain from damage, reduce inflammation, and improve cognitive function.1

They also contain compounds that may have anti-anxiety and anti-depressant effects. In addition, Lion's Mane mushrooms are a rich source of antioxidants, which can help protect the body from free radical damage. 

For these reasons, Lion's Mane mushrooms have become popular with those looking to improve their overall health and well-being.

How Do They Work?

So, how do Lion's Mane mushrooms work? Research suggests that the mushroom contains compounds known as beta-glucans, hericenones, and erinacines, which are unique compounds found only in this mushroom.2 These compounds have been shown to have various health benefits, including the potential to stimulate nerve growth factor (NGF) in the brain. Studies have found that NGF plays a role in cognitive function, including memory, learning, and focus. 3

Lion's mane appears to work by stimulating the production of NGF in the brain, which may help to protect and regenerate neurons and improve cognitive function. Its anti-inflammatory and antioxidant properties may also contribute to its potential health benefits for brain health

However, more research is needed to fully understand how Lion's mane works and its potential therapeutic applications.

Health Benefits Of Lion's Mane

Lion’s Mane is well known for its medicinal properties and is believed to have a variety of health benefits. The mushroom has been used to treat diverse ailments, including digestive issues, anxiety, depression, and even cancer. In recent years, it has gained more attention for its potential health benefits, including:

Helps With Anxiety And Depression

Lion's Mane mushroom extract has potential health benefits and may help reduce symptoms of anxiety and depression by promoting the growth of new brain cells and increasing the production of nerve growth factor (NGF). 

Studies in mice and humans have shown positive effects on mood and cognitive function, suggesting that it could be a potential natural treatment for anxiety and depression.4

Helps With Recovery From Nervous System Injuries

Lion's Mane mushroom extract has neuroprotective and neuroregenerative properties and can aid in recovery from nervous system injuries. Its bioactive compounds like hericenones, erinacines, and polysaccharides, protect and repair neurons.

Studies suggest that it can reduce inflammation and oxidative stress and promote the growth of new neurons in people with traumatic brain injuries and stroke.5

Helps With Cancer

Lion's Mane mushroom extract has been found to have anti-tumor and anti-metastatic properties that can help reduce the growth of cancer cells in various types of cancer, including breast, colon, prostate, and lung cancer.6 It may also help to reduce the side effects of chemotherapy and radiation therapy by reducing inflammation and damage caused by cancer treatments.7

Additionally, it has immunomodulatory properties that can help boost the immune system and fight off infection and disease, which can be beneficial for people with cancer. 

Boosts The Immune System

Lion's Mane mushroom extract has immune-boosting properties that can stimulate cytokine production, increase macrophage activity, and reduce inflammation and oxidative stress. These effects can help protect the body from various illnesses and infections by boosting the immune system's ability to fight off disease and infection.

Reduces Risk Of Heart Diseases

Studies have shown that Lion's Mane mushroom extract contains compounds such as beta-glucans that can help reduce cholesterol levels, lower blood pressure, and improve cardiovascular health. 2

Additionally, it may help reduce inflammation and oxidative stress, which are risk factors for heart disease. As a result, Lion's Mane mushroom extract may be an effective natural supplement for reducing the risk of heart disease and improving overall cardiovascular health.

Reduces Risk Of Dementia

Lion's Mane mushroom extract may be a promising natural remedy for reducing the risk of dementia, as studies have shown that it stimulates the growth of nerve cells, improves cognitive function and memory, and reduces inflammation in the brain.3 Its ability to protect the brain may help to reduce the risk of dementia.

Reduces Inflammation

Lion's mane mushroom extract has been found to be effective in reducing inflammation, both in animal and human studies.5 Inflammation is a natural response of the body to injury and infection and is a necessary part of the healing process. 

However, when inflammation persists for a long time, it can lead to various chronic illnesses and diseases. Lion’s mane may be effective in reducing inflammation in humans, which could positively affect a variety of chronic illnesses and diseases that are caused or exacerbated by inflammation.

Helps With Diabetes Symptoms

Lion's Mane mushroom extract has shown the potential to reduce diabetes symptoms. Studies have found that it can help lower fasting blood sugar levels and improve glucose tolerance in diabetic rats.6 With additional research, Lion's Mane extract could be beneficial for people with diabetes.

What Is ADHD?

ADHD (Attention-Deficit/Hyperactivity Disorder) is a neurodevelopmental disorder affecting a person's ability to concentrate, pay attention, and control impulses. It is typically diagnosed in childhood, but symptoms can persist into adulthood.

Symptoms Of ADHD

People with ADHD may exhibit hyperactive, impulsive, and/or inattentive behaviors. Hyperactive behaviors include fidgeting, restlessness, and excessive talking, while impulsive behaviors include interrupting others and acting without thinking. Inattentive behaviors include difficulty focusing on tasks, forgetfulness, and disorganization.

Common ADHD Treatments

Attention Deficit Hyperactivity Disorder (ADHD) is a common mental health condition that affects millions of children and adults. It is characterized by difficulty focusing, hyperactivity, and impulsivity.

ADHD can interfere with a person's ability to function effectively in various settings, including school, work, and social situations. However, ADHD can be treated with various methods, including stimulant and non-stimulant medications, behavioral therapy, parenting skills training, education and support, and lifestyle changes. 

It is important to note that more research is ongoing regarding the effective treatment of ADHD, which brings us to the next question.

Can You Take Lion's Mane For ADHD?

Lion's Mane mushroom extract is a natural supplement that has been suggested as a potential treatment for ADHD (Attention-Deficit/Hyperactivity Disorder). While there is limited research on its effectiveness, some studies have found that it may be beneficial in improving focus and concentration.

Lion's Mane And Cognitive Health

Lion's Mane mushrooms have been found to have beneficial effects on cognitive health, including memory, focus, and concentration. The active compounds in Lion's Mane mushrooms, such as hericenones and erinacines, have been shown to have neuroprotective, anti-inflammatory, and antioxidant properties that may help protect and support brain function. 

Studies have found that taking Lion's Mane extract can improve cognitive function in both mice and humans.3 In one study, mice that were given a single dose of Lion's Mane extract performed better on a maze task, completing it faster and with fewer errors than the control group.8

This suggests that Lion's Mane mushrooms could potentially be a natural and effective way to support cognitive health and potentially improve symptoms of anxiety and depression. 

However, more research is needed to determine the full extent of its effects on cognitive function and mental health.

Lion's Mane And Focus

Lion’s Mane mushroom extract has been studied for its potential to improve focus and concentration. Studies have shown that Lion’s Mane may help improve cognitive functions, including focus and concentration. 

A study conducted in Japan found that Lion’s Mane mushroom extract improved performance on short-term memory and concentration tests.9 Another study found that Lion’s Mane mushroom extract improved the ability to focus on a task and to maintain attention.1 This suggests that Lion’s Mane may help to improve focus and concentration in people with ADHD. 

How To Take Lion's Mane For ADHD

When it comes to taking Lion’s Mane for ADHD, there are a few different ways you can go about it. The most common method is to take a supplement that contains Lion’s Mane extract. These supplements are available in capsule, powder, and liquid form, and they typically contain a standardized amount of the active compounds found in the mushroom. 

Another way to take Lion’s Mane for ADHD is to make tea using dried mushrooms. This is a more traditional method of using Lion’s Mane and is believed to be more effective than taking a supplement. To make the tea, simply add a teaspoon of dried Lion’s Mane mushroom powder to a cup of hot water and let it steep for 10 minutes. You can then strain the tea and drink it. 

Finally, you can also take Lion’s Mane in the form of an extract. This is a more concentrated form of the mushroom and is believed to be more effective than capsules or tea. Extracts are typically taken in drops or sprays and are usually more expensive than capsules or tea. 

Regardless of your chosen method, it’s important to remember that Lion’s Mane is not a “quick fix” for ADHD. It takes time for the active compounds in the mushroom to build up in your system and start having an effect. It’s also important to note that Lion’s Mane is not a substitute for traditional ADHD medications. If you have been prescribed medication for your ADHD, continue taking it as directed.

Final Thoughts

In conclusion, Lion's Mane mushroom extract has the potential to be a natural nootropic for those suffering from ADHD. As mentioned above, studies have shown that Lion's Mane can help to improve mental clarity, focus, and concentration, as well as reduce symptoms of anxiety and depression. 

It may also help reduce inflammation, boost the immune system, and reduce the risk of heart disease and dementia. While more research is needed to determine the efficacy of Lion's Mane for treating ADHD, it is a promising natural supplement that could potentially help those with ADHD to improve their cognitive health and focus.

For additional topics of interest, check out:


How long does it take for Lion's Mane to work?

The effects of Lion’s mane can vary from person to person, but typically, you should start seeing the effects from a few days to a few weeks. Remember that the effects of lion’s mane are cumulative, so it’s important to take it consistently to get the best results.

What are Lion's Mane side effects?

Lion’s mane is generally considered safe and well-tolerated. However, some people may experience mild side effects such as nausea, stomach upset, and diarrhea. It’s important to consult a healthcare professional before taking lion’s mane if you have any existing medical conditions or are taking any medications.

Does Lion's Mane get you high?

No, Lion’s mane does not get you high. Lion’s mane is a natural nootropic supplement that is used to improve focus and concentration, not to get high.

What does Lion's Mane do to your brain?

Lion’s mane has been shown to have various cognitive-enhancing effects. It has been shown to improve focus, concentration, and memory and reduce anxiety and depression. It has also been found to help with nerve regeneration and reduce the risk of dementia and Alzheimer’s disease.

Can you take Adderall and Lion's Mane together?

It is generally not recommended to take lion’s mane and Adderall together. Lion’s mane is a natural nootropic supplement, while Adderall is a stimulant medication. Taking both together could potentially lead to serious side effects. It’s best to consult a healthcare professional before taking any combination of medications or supplements.


  1. Spelman, K., Sutherland, E., & Bagade, A. (2018, December 6). Herbal Medicine for Alzheimer's Disease: Lion's Mane (Hericium erinaceus). Journal of Restorative Medicine. Retrieved from 
  2. Khan, M. A., Tania, M., Liu, R., & Rahman, M. M. (2013). Hericium Erinaceus: an Edible Mushroom with Medicinal Values. Journal of complementary & integrative medicine, 10, /j/jcim.2013.10.issue -1/jcim-2013-0001/jcim-2013-0001.xml.
  3. Lai, P. L., Naidu, M., Sabaratnam, V., Wong, K. H., David, R. P., Kuppusamy, U. R., Abdullah, N., & Malek, S. N. (2013). Neurotrophic Properties of the Lion's mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International journal of medicinal mushrooms, 15(6), 539–554. 
  4. Laugero, K. D., Adkins, Y., Mackey, B. E., & Kelley, D. S. (2017). Emotion-Based Cognition in Mice Is Differentially Influenced by Dose and Chemical Form of Dietary Docosahexaenoic Acid. Nutrients, 9(9), 993.
  5. Kushairi, N., Phan, C. W., Sabaratnam, V., David, P., & Naidu, M. (2019). Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia. Antioxidants (Basel, Switzerland), 8(8), 261. 
  6. Liu, J.-Y., Hou, X.-X., Li, Z.-Y., Shan, S.-H., Chang, M.-C., Feng, C.-P., & Wei, Y. (2020). Isolation and structural characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its arrest of cell cycle at S-phage in colon cancer cells. International Journal of Biological Macromolecules, 157, 288–295. 
  7. Therkelsen, S. P., Hetland, G., Lyberg, T., Lygren, I., & Johnson, E. (2016). Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. PloS one, 11(3), e0150191.
  8. Rodriguez, Mya & Lippi, Stephen. (2022). Lion’s Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model. Behavioral Sciences. 12. 10.3390/bs12070235. 
  9. Lee, S. K., Ryu, S. H., Turk, A., Yeon, S. W., Jo, Y. H., Han, Y. K., Hwang, B. Y., Lee, K. Y., & Lee, M. K. (2020). Characterization of α-glucosidase inhibitory constituents of the fruiting body of Lion's mane mushroom (Hericium erinaceus). Journal of Ethnopharmacology262. j.jep.2020.113197
March 10, 2023 — Griffin Lynch

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