Cannabis 101: CBDa vs. CBD

Hemp is a complex plant with a range of beneficial compounds. Two of these compounds, CBDa and CBD, have been gaining attention for their potential therapeutic properties. But what exactly is the difference between CBDa and CBD?

In this guide, we'll explore the differences between CBDa and CBD, their potential therapeutic uses, and how they affect the body. We'll also look at how to take them together, and which is better for your needs. Finally, we'll answer some FAQs about CBDa and CBD.

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CBDa, or cannabidiolic acid, is a naturally occurring compound found in the Cannabis sativa plant that belongs to a broader range of compounds known as cannabinoids. CBDa is the raw form or predecessor of CBD, which can be a little confusing to new users who are used to the more popular compounds on the market. When decarboxylated (exposed to heat) in its raw form, it converts to its more well-known state, CBD. 

Studies have shown that CBDa may have anti-inflammatory, anti-nausea, anti-anxiety, and pain-relieving properties1. CBDa is believed to have a higher affinity for the endocannabinoid system than CBD, which means it may be more effective at providing therapeutic benefits, although it interacts differently with the endocannabinoid system than the latter.

CBDa has been found to have anti-inflammatory properties n some research. It works by blocking the production of certain inflammatory molecules, such as cytokines and prostaglandins. It has been studied for its potential to reduce inflammation in conditions such as arthritis, Crohn's disease, and irritable bowel syndrome.

Furthermore, CBDa has been found to reduce inflammation in the skin, which could help with conditions such as eczema and psoriasis.

While more research is needed to understand the full potential of CBDa for reducing inflammation, the current evidence suggests that it may be a beneficial supplement for those looking to reduce chronic inflammation.

CBDa shows promising results when studied for its potential anti-tumor properties. Studies have shown that CBDa can inhibit the growth of certain types of cancer cells, including breast cancer, colorectal cancer, and prostate cancer3,4,5 . Additionally, CBDa has been found to reduce the spread of certain types of cancer cells, which can help slow the progression of the disease.

Research on CBDa’s potential anti-tumor properties is still in its early stages. While results are promising, further research is needed to understand the potential benefits of CBDa for cancer patients fully.

Never replace your current cancer treatment plan with CBDa, and make sure to speak with your doctor about CBDa prior to taking it to learn more about potential interactions and whether or not it’s right for you.

Studies have shown that CBDa can reduce nausea in rats and mice6, and that it may also have antiemetic properties. Additionally, CBDa has been found to interact with the endocannabinoid system, which is responsible for regulating nausea and vomiting in the body. This suggests that CBDa may be able to help reduce nausea and vomiting in humans as well.

Studies have shown that CBDa has anti-anxiety effects, which could benefit people suffering from anxiety-related disorders. It has been shown to increase the levels of anandamide, a naturally occurring endocannabinoid, which is thought to reduce anxiety. CBDa could also help reduce stress and improve sleep, both of which are important for managing anxiety. 

CBDa and CBD have both been studied for their potential pain-relieving benefits. In one study, CBDa was found to help reduce pain and inflammation in rats with neuropathy, while in another, CBD helped reduce pain in mice.

While more research is needed to fully understand the potential pain-relieving benefits of CBDa and CBD, these compounds may offer some relief for those suffering from chronic pain.

Cannabidiol (CBD) is another compound found in the cannabis sativa plant. It's been studied for its potential to help with a wide range of conditions, including chronic pain, inflammation, anxiety, and even depression.

CBD works by interacting with the body's endocannabinoid system (ECS) and its receptors. It may help regulate various physiological functions, such as mood, appetite, and pain. It may also help reduce inflammation and promote balance in the body.

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While CBDa and CBD may be related, they are not the same.

CBDa is found in raw, unheated cannabis, while CBD is found in heated cannabis. CBDa is potentially more effective at reducing inflammation and may be more effective at treating certain conditions, although the two are often used to address symptoms of the same conditions. Ultimately, it is up to the individual to decide which compound is best for them.

CBDa interacts with the endocannabinoid system (ECS), the body’s natural system that helps regulate various functions, such as appetite, sleep, and mood. When CBDa is ingested, it is converted into CBD, which then binds to the ECS’s receptors and helps regulate the body’s functions.

CBDa also interacts with the body’s serotonin receptors, which are involved in regulating mood, appetite, and sleep. Other receptors that CBDa interacts with are CB1 and 5-HT1A, which help reduce nausea and anxiety.

Like CBDa, CBD also interacts with the body’s ECS. When CBD is ingested, it binds to the body’s endocannabinoid receptors. It has been shown to have potential benefits for a wide range of medical conditions, including anxiety, depression, chronic pain, inflammation, and seizures.

CBD has also been studied for its potential to help with a variety of skin conditions, including acne, psoriasis, and eczema. Additionally, CBD may be beneficial for those with insomnia, as it has been found to reduce the time it takes to fall asleep and improve the quality of sleep, although efficacy may vary from person to person.

Yes, you can take CBDa and CBD together, as they both interact differently with the body. However, take note that the effects when taking both compounds together may be different than when taking them separately.

When taking CBDa and CBD together, consider the dosage of each compound. Start with a low dose, and increase gradually to find the right balance for your needs. It is best to consult with your doctor before taking any new supplements, especially if you are taking any medications that could be negatively impacted by the introduction of cannabinoids.

CBDa is believed to have anti-inflammatory, anti-tumor, and anti-nausea properties, as well as potential pain relief and anti-anxiety effects. It’s also believed to be more effective in lower doses than CBD.

CBD, on the other hand, is a more widely available cannabinoid. It has similar potential therapeutic benefits to CBDa, but is believed to be more effective in higher doses. It’s also thought to be more effective in treating certain conditions, such as anxiety and inflammation.

Ultimately, it’s up to you to decide which is better for you. If you’re looking for a more potent effect, CBD may be the better choice. If you’re looking for a more subtle effect, CBDa may be the better option to go for. 

CBDa can be found in many dispensaries and health stores, as well as in online retailers.

It is important to look for CBDa products that have been tested for purity and potency. This is to ensure that the product contains the correct amount of CBDa and other cannabinoids, and that it is free from contaminants.

CBDa products come in tinctures, oils, capsules, edibles, or topical creams. Each of these forms offers different methods of delivery, so choose the one that best suits your needs.

By taking the time to research and purchase high-quality CBDa products and with the right dosage, you can be sure to get the most out of this cannabinoid. 

CBDa and CBD are both compounds found in cannabis that have potential health benefits, and they’re closely related. Each offers its own benefits, but you may have a much easier time sourcing quality CBD products. Here at BATCH, we make it easy to find the right CBD products that you can rely on.

All of our CBD products are formulated by our in-house chemists and made from organic, non-GMO hemp grown right here in Wisconsin. There are no fillers or additives in any of our products, and we offer vegan options too. Our seed-to-doorstep process ensures complete transparency (although we do back it up with third-party testing so you know exactly what’s in your product).

We also offer free shipping on orders over $25, subscriptions that help you save 25 percent on your favorite products, and free returns and exchanges after your purchase date. See where CBD fits into your lifestyle by shopping CBD products like our CBD gummies, tinctures, and topicals. Contact us if you have any questions we can help you with!

Read Also: 

• CBD: How Much To Feel The Relaxing Effects
• How Does CBD Oil Make You Feel: CBD Daily Use Guide
• What Is CBD? -- CBD 101

Sources:

1. Rock EM, Sticht MA, Limebeer CL, Parker LA. Cannabinoid Regulation of Acute and Anticipatory Nausea. Cannabis Cannabinoid Res. 2016 Apr 1;1(1):113-121. doi: 10.1089/can.2016.0006. PMID: 28861486; PMCID: PMC5576606.
2. Martini S, Gemma A, Ferrari M, Cosentino M, Marino F. Effects of Cannabidiol on Innate Immunity: Experimental Evidence and Clinical Relevance. International Journal of Molecular Sciences. 2023; 24(4):3125. https://doi.org/10.3390/ijms24043125
3. Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H. Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicol Lett. 2012 Nov 15;214(3):314-9. doi: 10.1016/j.toxlet.2012.08.029. Epub 2012 Sep 8. PMID: 22963825; PMCID: PMC4009504.
4. Nallathambi R, Mazuz M, Namdar D, Shik M, Namintzer D, Vinayaka AC, Ion A, Faigenboim A, Nasser A, Laish I, Konikoff FM, Koltai H. Identification of Synergistic Interaction Between Cannabis-Derived Compounds for Cytotoxic Activity in Colorectal Cancer Cell Lines and Colon Polyps That Induces Apoptosis-Related Cell Death and Distinct Gene Expression. Cannabis Cannabinoid Res. 2018 Jun 1;3(1):120-135. doi: 10.1089/can.2018.0010. PMID: 29992185; PMCID: PMC6038055.
5. De Petrocellis L, Ligresti A, Schiano Moriello A, Iappelli M, Verde R, Stott CG, Cristino L, Orlando P, Di Marzo V. Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms. Br J Pharmacol. 2013 Jan;168(1):79-102. doi: 10.1111/j.1476-5381.2012.02027.x. PMID: 22594963; PMCID: PMC3570006.
6. Bolognini D, Rock EM, Cluny NL, Cascio MG, Limebeer CL, Duncan M, Stott CG, Javid FA, Parker LA, Pertwee RG. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. Br J Pharmacol. 2013 Mar;168(6):1456-70. doi: 10.1111/bph.12043. PMID: 23121618; PMCID: PMC3596650.
7. Crippa JA, Guimarães FS, Campos AC, Zuardi AW. Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Front Immunol. 2018;9:2009.

CBDa is a non-psychoactive compound, meaning it does not produce the “high” associated with cannabis consumption. CBDa may be beneficial for managing inflammation, reducing nausea, and relieving anxiety. However, individual experiences may vary.

CBDa is unlikely to cause drowsiness. However, experience may vary from person to person. CBD is known to cause fatigue in some users, so it stands to reason that users may experience this with CBDa. Testing it out can help you better understand how it affects you. You should also take your dose into consideration as this can have an impact on the severity of side effects like fatigue. 

Research suggests that CBDa may have potential anti-anxiety effects. It is important to speak with a healthcare professional before using CBDa or any other cannabis-derived product for anxiety. CBDa and other cannabinoids are not a suitable replacement for prescription medication and/or talk therapy.

The amount of time CBDa stays in your system depends on several factors, such as your body weight, metabolism, and how much you have consumed. Generally, CBDa is believed to stay in your system for up to 48 hours.